Plasma methionine enkephalin concentration and prognosis in primary biliary cirrhosis.
نویسندگان
چکیده
منابع مشابه
Opioid peptides and primary biliary cirrhosis.
Patients with liver disease have increased plasma concentrations of the endogenous opioid peptides methionine enkephalin and leucine enkephalin. As an initial investigation to determine whether opioid peptides contribute to any of the clinical manifestations of hepatic disease nalmefene, a specific opioid antagonist devoid of agonist activity, was given to 11 patients with cirrhosis. They all e...
متن کاملPlasma leucine enkephalin is increased in liver disease.
Plasma methionine enkephalin is increased in liver disease and may contribute to some of the clinical manifestations of hepatic failure. To determine if another 'small' opioid peptide is increased in the plasma of patients with liver disease, leucine enkephalin was measured by radioimmunoassay. Its plasma concentration was raised approximately five-fold in patients with acute liver disease (med...
متن کاملIs ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides?
Methionine enkephalin and catecholamines were measured in carefully collected plasma samples from 25 patients with cirrhosis and ascites, and 25 with cirrhosis without ascites, 15 disease and 15 healthy controls. Methionine enkephalin was invariably raised in the ascites group, the median value being 4.6-6.9 times that of the other three groups. Similarly, in the ascites group, median noradrena...
متن کاملبررسی اپیدمیولوژیک و دموگرافیک بیماران مبتلا به سیروز صفراوی اولیه شناخته شده در شهرستان اصفهان از سال 96-1388
Introdution: Primary biliary cirrhosis is a chronic cholestatic disease of the liver, characterized by the inflammation plus progressive and non-purulent destruction of the small biliary ducts, and the presence of auto antibodies against mitochondrial self-antigens. It seems that the prevalence of PBC in the western world is more than other parts of the world. This study aimed to identify all t...
متن کاملReferral of patients with primary biliary cirrhosis for liver transplantation.
All patients with primary biliary cirrhosis referred to this unit for consideration for transplantation between April 1981 and January 1989 were analysed retrospectively to assess whether disease stage at referral affects the outcome after grafting and whether greater awareness of the benefits of the procedure means that patients are now being referred at an earlier stage. Seventy of the 107 pa...
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عنوان ژورنال:
- BMJ
دوره 297 6658 شماره
صفحات -
تاریخ انتشار 1988